circRNA basic information
circBase ID: -
Name: hsa_circ_GFRA1
Synonym: hsa_circRNA_100689
Host Gene: GFRA1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF7; MCF10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Differentially expressed in Luminal subtype breast cancer cells and may provide a basis for early diagnosis or target discovery; specific biological function was not determined.
Molecular mechanism: Not determined in this study.
Biological pathway or process:

not specified (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR
Clinical significance:

Potential diagnostic or therapeutic target for Luminal subtype breast cancer, not clinically validated.
Description:

hsa_circRNA_100689 is a GFRA1-associated circRNA up-regulated in MCF7 Luminal breast cancer cells compared with MCF10A normal breast epithelial cells. Its differential expression was detected by circRNA microarray and validated by qPCR, suggesting potential relevance to Luminal breast cancer biology or marker discovery, but its mechanism was not experimentally defined.
Confidence score:

0.3401
Other information
Title:

[Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Published: 2018
PubMed ID: 30187868
Study type:

combined biological and bioinformatics study
Data availability: -
Code availability: -