circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched non-tumor tissues
Cell lines:

SiHa; HeLa; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FGF2
Associated microRNA: miR-485-3 p
Biological function: Promotes cervical cancer cell proliferation, migration and invasion; knockdown inhibits cervical cancer cell proliferation and metastasis.
Molecular mechanism: circHIPK3 acts through a ceRNA mechanism by adsorbing miR-485-3 p, thereby positively regulating FGF2 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; BrdU; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

May provide clues for the diagnosis and treatment of cervical cancer.
Description:

circHIPK3 is up-regulated in cervical cancer tissues and functions as an oncogenic circRNA. It promotes cervical cancer cell proliferation, migration and invasion by sponging miR-485-3 p and indirectly increasing FGF2 expression through a ceRNA mechanism.
Confidence score:

0.6536
Other information
Title:

Circular RNA HIPK3 plays a carcinogenic role in cervical cancer progression via regulating miR-485-3p/FGF2 axis.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Published: 2021
PubMed ID: 33177072
Study type:

combined biological and clinical study
Data availability: The data used to support the findings are available from the corresponding author on reasonable request.
Code availability: -