| Expression pattern: |
UP |
| Associated gene: |
EGFR, IGF2BP3, Ago2 |
| Associated microRNA: |
miR-450a |
| Biological function: |
promotes HCC cell proliferation, migration and invasion; promotes tumor growth and metastasis; inhibits apoptosis (via miR-450a regulation) |
| Molecular mechanism: |
circCOCH acts as a miR-450a sponge to upregulate EGFR and activate EGFR-induced PI3K/AKT/mTOR signaling; IGF2BP3 mediates circCOCH biogenesis by binding flanking intronic sequences |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circCOCH expression in HCC tissues was significantly higher than in normal tissues, suggesting its potential as a biomarker for HCC patients; study lacks samples for survival analysis |
| Description: |
circCOCH (hsa_circ_0031431), derived from the COCH gene, is up-regulated in HCC tissues and cell lines and mainly localized in the cytoplasm. It promotes HCC proliferation and metastatic phenotypes by sponging miR-450a to increase EGFR expression and activate the EGFR-driven PI3K/AKT/mTOR pathway; IGF2BP3 supports its biogenesis via binding flanking intronic sequences. |
| Confidence score: |
0.8412 |