circRNA basic information
circBase ID: -
Name: hsa_circ_PLOD2
Synonym: circPLOD2
Host Gene: PLOD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; healthy brain
Cell lines:

U-118 MG; U-251 MG
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FUS
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Binds FUS in GBM cells (enrichment after CLIP/anti-FUS IP). Knockdown did not produce functional relevant proliferation changes.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CLIP; RIP (RNA Immunoprecipitation); Western Blot
Clinical significance:

-
Description:

circPLOD2 is up-regulated in GBM and localized in both nucleus and cytoplasm. It can bind the RBP FUS in CLIP-based assays, but its knockdown did not produce functional relevant proliferation changes under the tested conditions.
Confidence score:

0.6783
Other information
Title:

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.

Journal: Molecular oncology
Published: 2025
PubMed ID: 40008750
Study type:

combined biological and clinical study
Data availability: GSE196695
Code availability: https://github.com/MSajek/GBM_circs