| Expression pattern: |
UP |
| Associated gene: |
ROCK1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes NPC cell proliferation, cell cycle progression, migration, invasion and metastasis; functions as an oncogene in NPC. |
| Molecular mechanism: |
circ-ABCB10 promotes NPC progression by upregulating ROCK1. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Upregulated circ-ABCB10 was associated with tumor size and lymphatic metastasis; circ-ABCB10 could serve as a promising mark for NPC. |
| Description: |
circ-ABCB10 (hsa_circ_0008717) is upregulated in nasopharyngeal carcinoma tissues and cell lines. The study indicates that circ-ABCB10 acts as an oncogenic circRNA that promotes NPC cell proliferation, cell cycle progression, migration, invasion and metastasis, at least partly by upregulating ROCK1. Its higher expression is associated with tumor size and lymphatic metastasis, suggesting potential clinical biomarker value. |
| Confidence score: |
0.5761 |