| Expression pattern: |
UP |
| Associated gene: |
ALG8, AGO2 |
| Associated microRNA: |
miR-431-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, and metastasis; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-431-5p to regulate ALG8 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (other); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0001742 expression is correlated with poor prognosis in CRC patients. |
| Description: |
circ_0001742 (hsa_circ_0001742) is up-regulated in CRC cells/tissues and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-431-5p to de-repress ALG8, forming the circ_0001742/miR-431-5p/ALG8 axis. High circ_0001742 expression is associated with poor overall survival in CRC patients. |
| Confidence score: |
0.8658 |