| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
miR-7 |
| Biological function: |
promotes docetaxel resistance; inhibits apoptosis; promotes proliferation/viability and colony formation; promotes cell cycle progression; promotes tumor growth |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism via binding miR-7 |
| Biological pathway or process: |
drug resistance (inhibits); apoptosis (inhibits); proliferation (promotes); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0000735 expression had a shorter overall survival; promising prognostic biomarker for PCa |
| Description: |
hsa_circ_0000735 is up-regulated in docetaxel-resistant prostate cancer tissues/cells and promotes docetaxel resistance. It mainly functions as a cytoplasmic miR-7 sponge, thereby enhancing malignant behaviors and reducing apoptosis; knockdown increases docetaxel sensitivity and suppresses tumor growth in vivo. High expression is associated with shorter overall survival. |
| Confidence score: |
0.8571 |