| Expression pattern: |
DN |
| Associated gene: |
Rb |
| Associated microRNA: |
miR-574-3p |
| Biological function: |
circRNA_100782 is downregulated in gastric cancer; upregulation of circRNA_100782 inhibits gastric cancer cell proliferation, migration and invasion, whereas downregulation promotes migration and invasion. |
| Molecular mechanism: |
circRNA_100782 acts as a ceRNA and molecular sponge for miR-574-3p to regulate the expression of the tumor suppressor gene Rb. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
low expression of circRNA_100782 was associated with poor prognosis of gastric cancer |
| Description: |
circRNA_100782 is significantly downregulated in gastric cancer tissues and SGC-7901 cells. Functional assays indicate that restoring circRNA_100782 suppresses gastric cancer cell proliferation, migration and invasion, while knockdown has the opposite effect. Mechanistically, circRNA_100782 acts as a miR-574-3p sponge/ceRNA to modulate Rb expression, and low circRNA_100782 expression is associated with poor prognosis. |
| Confidence score: |
0.6987 |