| Expression pattern: |
UP |
| Associated gene: |
MUC1 |
| Associated microRNA: |
miR-122-5p |
| Biological function: |
Promotes HCC cell proliferation, migration and invasion; promotes HCC growth in vivo. |
| Molecular mechanism: |
Acts as a sponge for miR-122-5p to regulate MUC1 expression (ceRNA axis), supported by dual-luciferase assays and rescue experiments. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation; Microarray |
| Clinical significance: |
- |
| Description: |
hsa_circ_0055054 is up-regulated in HCC and promotes HCC cell proliferation, migration and invasion. It functions as a ceRNA by binding miR-122-5p, thereby increasing MUC1 expression; circRNA knockdown suppresses tumor growth in a MHCC97L xenograft model. |
| Confidence score: |
0.7416 |