| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-101-3p |
| Biological function: |
hsa_circ_103809 promotes migration and invasion of gastric cancer cells; knockdown of hsa_circ_103809 suppresses gastric cancer cell migration and invasiveness. |
| Molecular mechanism: |
hsa_circ_103809 functions as a ceRNA and sponges microRNA-101-3p, thereby promoting malignant progression, migration and invasion of gastric cancer cells. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_103809 expression predicts poor prognosis of gastric cancer patients and may be used as a marker for predicting poor prognosis. |
| Description: |
hsa_circ_103809 is up-regulated in gastric cancer tissues and cell lines and high expression is associated with poor prognosis. Functionally, it promotes gastric cancer cell migration and invasion. Mechanistically, it acts as a ceRNA/sponge for microRNA-101-3p, and hsa_circ_103809 overexpression reverses the inhibitory effect of microRNA-101-3p on gastric cancer cell migration and invasion. |
| Confidence score: |
0.6987 |