circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005109
MONDO name: HIV infectious disease
Disease details: HIV-1 infection
Disease DO ID:
 526
Disease MeSH ID:
 D015658
Disease NCIt ID:
 C3108
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; PBMC; circulating CD4+ T lymphocytes; activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-26b-3p, hsa-miR-149-5p
Biological function: Exclusive to viremic patients; proposed to participate in competing endogenous networks potentially influencing viral replication.
Molecular mechanism: Predicted MRE/miRNA sequestration in circRNA-miRNA-mRNA network.
Biological pathway or process:

ceRNA regulation (other); viral replication (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

CircRNA candidate exclusive to viremic patients and undetectable after ART; proposed as viremia-associated biomarker/target candidate.
Description:

circZNF609 (hsa-ZNF609_0001) was detected in all viremic (pre-ART) patients and became undetectable after ART suppression. It was assigned predicted miRNA response elements (e.g., miR-26b-3p, miR-149-5p) and incorporated into predicted circRNA-miRNA-mRNA competing networks related to viremic status.
Confidence score:

0.1768
Other information
Title:

Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.

Journal: Viruses
Published: 2022
PubMed ID: 35458413
Study type:

bioinformatics study
Data availability: SRP068424
Code availability: Dora Zucko GitHub; Grinde Lab GitHub