| Expression pattern: |
UP |
| Associated gene: |
61 mRNAs |
| Associated microRNA: |
hsa-miR-664b-3p, hsa-miR-139-5p, hsa-miR-6509-5p, hsa-miR-323a-3p, hsa-miR-370-3p, hsa-miR-181a-5p, hsa-miR-181b-5p |
| Biological function: |
Predicted to participate in CRC-associated ceRNA regulation, apoptotic processes and metabolic processes; may contribute to anti-apoptosis and tumor survival. |
| Molecular mechanism: |
Predicted ceRNA mechanism through a circRNA/miRNA/mRNA regulatory network. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (inhibits); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May facilitate the finding of promising targets and biomarkers in CRC. |
| Description: |
hsa_circ_0004887 is up-regulated in CRC according to RNA-seq/GEO intersection and qPCR results, although its expression level was reported to be low and difficult to detect. The study predicts that it may function in CRC through a circRNA/miRNA/mRNA ceRNA network involving apoptotic and metabolic processes. |
| Confidence score: |
0.585 |