| Expression pattern: |
DN |
| Associated gene: |
NTRK3 |
| Associated microRNA: |
hsa-miR-1278, hsa-miR-140-3p, hsa-miR-197, hsa-miR-599, hsa-miR-637 |
| Biological function: |
Associated with cancer-related biological processes including metastasis (cell migration and cell-cell adhesion) and proliferation (regulation of cell cycle and cell differentiation) in breast cancer; proposed as a diagnostic biomarker. |
| Molecular mechanism: |
Predicted miRNA sponge (ceRNA-like) mechanism via binding multiple miRNAs (top 5 predicted). |
| Biological pathway or process: |
migration (other); metastasis (other); proliferation (other); cell cycle (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Downregulated in breast cancer tissues and peripheral blood and shows diagnostic value by ROC analysis (AUC 0.823 in tissues; AUC 0.849 in peripheral blood). |
| Description: |
hsa_circ_0104824 (host gene NTRK3) is significantly downregulated in breast cancer tissues and in patient peripheral blood. It shows good diagnostic performance by ROC analysis and is proposed to act as an miRNA sponge based on bioinformatic predictions, with inferred links to metastasis- and proliferation-related processes. |
| Confidence score: |
0.5047 |