circRNA basic information
circBase ID: hsa_circ_0040573
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:78458766-78466649:+
Genomic location(hg38): chr16:78424869-78432752:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RAC1
Associated microRNA: hsa-miR-3686
Biological function: Suggested to play roles in malignant transformation and metastasis of GC (within the proposed hsa_circ_0040573-hsa-miR-3686-RAC1 network).
Molecular mechanism: Proposed ceRNA relationship: hsa_circ_0040573-hsa-miR-3686-RAC1; RAC1 linked to Fc gamma R-mediated phagocytosis and cAMP signaling.
Biological pathway or process:

cAMP signaling (other); other pathway/process (other); metastasis (promotes); invasion (promotes); migration (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0040573 is reported as up-regulated in gastric cancer by integrated microarray analysis and external dataset validation. The paper proposes a ceRNA pair hsa_circ_0040573-hsa-miR-3686-RAC1 (with immune-cell correlation), suggesting involvement in GC malignant transformation and metastasis, but without experimental mechanistic assays.
Confidence score:

0.1768
Other information
Title:

Identification of circRNA-miRNA-Immune-Related mRNA Regulatory Network in Gastric Cancer.

Journal: Frontiers in oncology
Published: 2022
PubMed ID: 35280778
Study type:

bioinformatics study
Data availability: GSE83521; GSE89143; GSE93541; GSE141977
Code availability: -