circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: hsa_circRNA_102049
Host Gene: TADA2A
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent non-tumor tissues
Cell lines:

NCM460; SW480; LOVO; HT29; DLD-1; SW620; HCT116; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-455-3p
Biological function: Promotes colorectal cancer cell proliferation, migration and invasion; promotes cell cycle entry; inhibits apoptosis.
Molecular mechanism: Acts as a miRNA sponge/ceRNA by directly binding miR-455-3p and suppressing its expression; validated with dual-luciferase reporter assay and rescue experiments using miR-455-3p mimic/inhibitor.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay
Clinical significance:

hsa_circRNA_102049 expression was associated with clinicopathological features of CRC patients (differentiation, TNM stage, lymphatic migration and invasion, histological classification) and may be a potential biomarker/therapeutic target.
Description:

hsa_circRNA_102049 (alias hsa_circ_0043278, host gene TADA2A) is upregulated in colorectal cancer tissues and cell lines. It promotes CRC proliferation, cell-cycle progression, migration and invasion and inhibits apoptosis by sponging/binding miR-455-3p, supported by luciferase and rescue experiments.
Confidence score:

0.6542
Other information
Title:

Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p.

Journal: Experimental and therapeutic medicine
Published: 2022
PubMed ID: 35222721
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: -