circRNA basic information
circBase ID: hsa_circ_0003204
Name: hsa_circ_USP36
Synonym: -
Host Gene: USP36
Genomic location(hg19): chr17:76798405-76800060:-
Genomic location(hg38): chr17:78802323-78803978:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005311
MONDO name: atherosclerosis
Disease details: Atherosclerosis
Disease DO ID:
 1936
Disease MeSH ID:
 D050197
Disease NCIt ID:
 C35768
Disease ICD11 ID:
 109367356
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HAECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Nod2
Associated microRNA: miR-330-5p
Biological function: Promotes oxidative stress and apoptosis in ox-LDL-induced endothelial cell injury; knockdown mitigates endothelial cell injury.
Molecular mechanism: Acts as a ceRNA by sponging miR-330-5p to regulate Nod2 expression, thereby affecting oxidative stress and apoptosis.
Biological pathway or process:

apoptosis (promotes); other pathway/process (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

In an ox-LDL-induced endothelial injury (atherosclerosis cell model), hsa_circ_0003204 is up-regulated and promotes oxidative stress and apoptosis. Silencing hsa_circ_0003204 alleviates injury by sponging miR-330-5p and reducing Nod2 expression (hsa_circ_0003204/miR-330-5p/Nod2 axis).
Confidence score:

0.5554
Other information
Title:

Knockdown of circular RNA hsa_circ_0003204 inhibits oxidative stress and apoptosis through the miR-330-5p/Nod2 axis to ameliorate endothelial cell injury induced by low-density lipoprotein.

Journal: Central-European journal of immunology
Published: 2021
PubMed ID: 34764783
Study type:

biological research
Data availability: -
Code availability: -