| Expression pattern: |
UP |
| Associated gene: |
CCND1, Ago2 |
| Associated microRNA: |
miR-369-3p |
| Biological function: |
promotes CRC cell proliferation, migration, invasion, EMT, and immune escape; inhibits apoptosis |
| Molecular mechanism: |
ceRNA/miRNA sponge: hsa_circ_0000423 competitively binds miR-369-3p to indirectly increase CCND1 expression, affecting EMT and immune escape (PD-L1) in CRC cells |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); immune regulation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; ELISA; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0000423 level was correlated with tumor size, distant metastasis, and clinical stage. |
| Description: |
In colorectal cancer, hsa_circ_0000423 is up-regulated and promotes proliferation, migration/invasion, EMT, and immune escape while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-369-3p to increase CCND1 expression, and its knockdown reduces PD-L1 and enhances T-cell-mediated anti-tumor responses in co-culture. |
| Confidence score: |
0.8122 |