circRNA basic information
circBase ID: hsa_circ_0043947
Name: hsa_circ_BRCA1
Synonym: -
Host Gene: BRCA1
Genomic location(hg19): chr17:41199659-41215968:-
Genomic location(hg38): chr17:43047642-43063951:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; plasma
Cell lines:

SGC-7901; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NRIP1, CD38, ATP6AP2, ITGA6, MARCKSL1, COL4A1, ATP8A1, TWIST1, IL12RB2, TFCP2
Associated microRNA: hsa-miR-1257, hsa-miR-140-3p, hsa-miR-151a-3p, hsa-miR-660-5p
Biological function: unknown
Molecular mechanism: Predicted circRNA-miRNA-mRNA (ceRNA) network based on bioinformatics
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection
Clinical significance:

The network may become a new molecular biomarker
Description:

hsa_circ_0043947 is up-regulated in gastric cancer tissue and plasma datasets and is higher in SGC-7901 than GES-1 by RT-qPCR. It is incorporated into a predicted ceRNA (circRNA-miRNA-mRNA) network via bioinformatics, but no dedicated functional mechanism is experimentally validated in this study.
Confidence score:

0.3684
Other information
Title:

Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.

Journal: World journal of surgical oncology
Published: 2022
PubMed ID: 35164778
Study type:

combined biological and clinical study
Data availability: GSE83521; GSE93541
Code availability: -