| Expression pattern: |
UP |
| Associated gene: |
FLNA, MMP2 |
| Associated microRNA: |
miR-486-3p |
| Biological function: |
Promotes LSCC cell migration and is correlated with lymph node metastasis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-486-3p, relieving miR-486-3p repression of FLNA and increasing FLNA (and MMP2) protein expression to promote migration. |
| Biological pathway or process: |
migration (promotes); invasion (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Higher expression of circFLNA was correlated with LSCC lymph node metastasis. |
| Description: |
circFLNA (hsa_circ_0092012), derived from FLNA, is up-regulated in LSCC and correlates with lymph node metastasis. It promotes LSCC cell migration by sponging miR-486-3p, thereby relieving miR-486-3p-mediated suppression of FLNA and increasing FLNA (and MMP2) protein levels. |
| Confidence score: |
0.7475 |