| Expression pattern: |
UP |
| Associated gene: |
ALKBH5, YTHDF2, p65, MYB, HIF1A, Ago2 |
| Associated microRNA: |
hsa-miR-503-5p |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes metastasis; promotes tumour growth |
| Molecular mechanism: |
ALKBH5-mediated m6A modification enhances circCCDC134 stability in a YTHDF2-dependent manner; circCCDC134 recruits p65 in the nucleus to enhance HIF1A transcription; circCCDC134 acts as a miRNA sponge (miR-503-5p) to upregulate MYB, which stimulates HIF1A transcription |
| Biological pathway or process: |
HIF-1 signaling (promotes); TNF signaling (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (other); m6A modification (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; circRIP; RIP (RNA Immunoprecipitation); MeRIP / MeRIP-seq; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; ChIP / ChIP-seq; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circCCDC134 is a novel potential biomarker and therapeutic target in CC. |
| Description: |
circCCDC134 is up-regulated in cervical cancer (especially metastatic tissues) and promotes proliferation, migration, invasion and metastasis. Mechanistically, ALKBH5-mediated m6A modulation affects its stability via YTHDF2; circCCDC134 recruits p65 to enhance HIF1A transcription and sponges hsa-miR-503-5p to upregulate MYB, which further stimulates HIF1A transcription. |
| Confidence score: |
0.8871 |