circRNA basic information
circBase ID: hsa_circ_0001522
Name: hsa_circ_CSNK1G3
Synonym: hsa_circCSNK1G3_004
Host Gene: CSNK1G3
Genomic location(hg19): chr5:122881110-122893258:+
Genomic location(hg38): chr5:123545416-123557564:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019091
MONDO name: bronchopulmonary dysplasia
Disease details: bronchopulmonary dysplasia / BPD
Disease DO ID:
 11650
Disease MeSH ID:
 D001997
Disease NCIt ID:
 C90599
Disease ICD11 ID:
 1462855296
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; serum; serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for BPD prediction (weaker than hsa_circ_0001359).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis
Clinical significance:

Day-7 hsa_circ_0001522 showed modest predictive value for BPD (AUC 0.657).
Description:

This study identified serum exosomal hsa_circ_0001522 as continuously differentially expressed between BPD and non-BPD preterm infants and validated its differential expression by RT-qPCR. It showed modest predictive ability for BPD on day 7 (AUC 0.657), and no specific downstream mechanism was experimentally investigated.
Confidence score:

0.5202
Other information
Title:

Hsa_circ_0001359 in Serum Exosomes: A Promising Marker to Predict Bronchopulmonary Dysplasia in Premature Infants.

Journal: Journal of inflammation research
Published: 2024
PubMed ID: 39081873
Study type:

combined biological and clinical study
Data availability: The dataset used during this study is available from the corresponding author upon reasonable request.
Code availability: -