| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-423-5p |
| Biological function: |
Predicted upregulated ceRNA-network circRNA associated with miR-423-5p; its target mRNA group showed a rightward ECDF shift suggesting higher expression of miRNA target mRNAs in Hep3B cells. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving miR-423-5p and derepression of miRNA target mRNAs. |
| Biological pathway or process: |
ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circSPECC1L was included among analyzed upregulated validated circRNAs in the ceRNA workflow. It was predicted to associate with miR-423-5p, and the corresponding target mRNA distribution suggested potential derepression of downstream targets in HBV-integrated Hep3B cells. |
| Confidence score: |
0.4761 |