circRNA basic information
circBase ID: hsa_circ_0008285
Name: hsa_circ_CDYL
Synonym: Circ-0008285
Host Gene: CDYL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005229
MONDO name: bacterial infectious disease with sepsis
Disease details: sepsis
Disease DO ID:
 0040085
Disease MeSH ID:
 D016470
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: interferon regulatory factor 4, C/EBP-delta
Associated microRNA: Let-7c
Biological function: potential biomarker for severe sepsis
Molecular mechanism: bioinformatically predicted interaction network with miRNAs and mRNAs (not experimentally validated in this study)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

potential biomarker for severe sepsis
Description:

hsa-circ-0008285 (from CDYL exons) is significantly up-regulated in plasma of male severe sepsis patients and was validated by qPCR. The study proposes it as a potential biomarker, and bioinformatics predicts a broad interaction network with miRNAs and mRNAs.
Confidence score:

0.585
Other information
Title:

Circular RNAs as potential biomarkers for male severe sepsis.

Journal: Open life sciences
Published: 2024
PubMed ID: 39071490
Study type:

combined biological and clinical study
Data availability: GSE244903
Code availability: -