| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, N-cadherin, vimentin, Snail, Slug |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
Inhibits proliferation, migration and invasion (metastasis) of HCC cells; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge to directly bind miR-590-5p; suppresses EMT-related changes. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Down-regulated circEPB41L2 expression in HCC tissues is associated with bigger tumor size, vascular invasion, higher AFP, and worse RFS/OS; circEPB41L2 is an independent prognostic factor for OS. |
| Description: |
circEPB41L2 (hsa_circ_0077837), derived from EPB41L2, is down-regulated in HCC tissues and acts as a tumor suppressor. It inhibits HCC cell proliferation, migration and invasion and suppresses tumor growth in a xenograft model, at least partly by sponging miR-590-5p and modulating EMT-related markers. |
| Confidence score: |
0.8545 |