| Expression pattern: |
UP |
| Associated gene: |
CCBE1, c-Myc, cyclin D1, MACC1 |
| Associated microRNA: |
miR-1205 |
| Biological function: |
promotes cell growth/proliferation and metastatic potential (migration/invasion) and inhibits apoptosis; promotes lung metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0006174 sponges miR-1205 to upregulate CCBE1 and activate Wnt pathway-related proteins (c-Myc, cyclin D1) |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); Wnt/beta-catenin (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; TUNEL; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Circ_0006174 overexpression was associated with larger tumor diameter and higher T stage of CRC patients; potential diagnostic biomarker and therapy target |
| Description: |
circ_0006174 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes proliferation, migration/invasion and lung metastasis while inhibiting apoptosis by sponging miR-1205 to increase CCBE1 and activate Wnt pathway-related proteins (e.g., c-Myc and cyclin D1). |
| Confidence score: |
0.6975 |