| Expression pattern: |
DN |
| Associated gene: |
RAPGEF1, C3G, p38MAPK |
| Associated microRNA: |
miR-483-3p |
| Biological function: |
May protect against AGEs-induced HUVECs damage by participating in inhibition of p38MAPK-related cellular inflammation and mitochondrial apoptosis pathways. |
| Molecular mechanism: |
ceRNA mechanism involving the ZNF609/MSTRG.35979-miR-483-3p-RAPGEF1 regulatory axis and downstream p38MAPK-related inflammation and apoptosis pathways. |
| Biological pathway or process: |
MAPK (inhibits); NF-kappaB (inhibits); apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
ZNF609 was identified as the circRNA component of a ceRNA-related regulatory axis in AGEs-induced HUVEC damage. It was down-regulated after AGEs injury and restored by LMP treatment, and the proposed ZNF609/MSTRG.35979-miR-483-3p-RAPGEF1 axis may inhibit p38MAPK-associated inflammation and mitochondrial apoptosis. |
| Confidence score: |
0.4375 |