circRNA basic information
circBase ID: hsa_circ_0000219
Name: hsa_circ_FAM188A
Synonym: -
Host Gene: FAM188a
Genomic location(hg19): chr10:15858833-15889942:-
Genomic location(hg38): chr10:15816834-15847943:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GBM tissue; normal brain tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ARHGEF7, CELA2b, RNF11, YPEL1, ZNF37a
Associated microRNA: hsa-miR-1248
Biological function: unknown
Molecular mechanism: Potential ceRNA (molecular sponge) network with hsa-miR-1248 and downstream targets screened via TCGA.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
M
Validation methods:

RNA-seq; Microarray; Bioinformatics Analysis
Clinical significance:

May have the potential being emerging glioblastoma therapeutic targets (requires further experiments).
Description:

hsa_circ_0000219 was identified as a common down-regulated circRNA in GBM across multiple GEO datasets and incorporated into a predicted circRNA-miRNA-mRNA sponge network. It is predicted to interact with hsa-miR-1248 and may affect downstream genes (e.g., RNF11 and others) based on database screening, but lacks experimental validation.
Confidence score:

0.2465
Other information
Title:

Bioinformatics analysis of potential glioblastoma circular RNA sponge network.

Journal: Translational cancer research
Published: 2022
PubMed ID: 35706804
Study type:

bioinformatics study
Data availability: GSE146463; GSE92322; GSE86202; TCGA-GBM; https://cdn.amegroups.cn/static/public/tcr-21-2597-01.zip
Code availability: -