| Expression pattern: |
UP |
| Associated gene: |
CIRBP, YAP1, EIF4A3, CRIM1 pre-mRNA, EIF4A4 |
| Associated microRNA: |
miR-383-5p |
| Biological function: |
promotes proliferation; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge of miR-383-5p to upregulate CIRBP and activate PI3K/AKT signaling; hypoxia-enhanced YAP1-EIF4A3 interaction promotes circ_0007386 biogenesis by affecting CRIM1 pre-mRNA splicing/circularization |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); PI3K/AKT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; TUNEL; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; RIP (RNA Immunoprecipitation); Co-IP; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher expression of circ_0007386 is associated with worse overall survival and correlates with clinical features in NSCLC patients. |
| Description: |
circ_0007386 is up-regulated in NSCLC and predominantly localized in the cytoplasm. It promotes NSCLC cell proliferation and tumor growth and inhibits apoptosis by sponging miR-383-5p to increase CIRBP, thereby activating PI3K/AKT signaling. Under hypoxia, enhanced YAP1-EIF4A3 interaction favors CRIM1 back-splicing and increases circ_0007386 biogenesis; high circ_0007386 predicts poorer overall survival. |
| Confidence score: |
0.8933 |