| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-346 |
| Biological function: |
may be involved in maintaining docetaxel sensitivity; down-regulation may reduce inhibition of miR-346 contributing to docetaxel resistance |
| Molecular mechanism: |
predicted miRNA sponge interaction with miR-346; pathway-level association with PI3K-Akt and AGE-RAGE signaling based on target enrichment of eligible miRNAs |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circEPHA3.1 is strongly down-regulated in docetaxel-resistant breast cancer cell lines. It is proposed to modulate docetaxel response by sponging miR-346; loss of circEPHA3.1 may relieve miR-346 inhibition and contribute to resistance, with pathway associations inferred from enrichment analyses. |
| Confidence score: |
0.4761 |