circRNA basic information
circBase ID: hsa_circ_0004503
Name: -
Synonym: circ_0004503
Host Gene: -
Genomic location(hg19): chr5:138979956-139003046:+
Genomic location(hg38): chr5:139600371-139623461:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary breast cancer tissue; brain metastasis tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PHLDA1, SLC12A2, MMP2, RGP1, MAP2K6
Associated microRNA: -
Biological function: Identified as an upregulated circRNA in a brain-metastasis-associated circRNA-miRNA-mRNA network in basal-like breast cancer.
Molecular mechanism: Predicted ceRNA involvement in circRNA-miRNA-mRNA network (specific miRNAs not reported for circ_0004503).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0004503 is reported as up-regulated in basal-like breast cancer brain metastasis (vs primary) and is included as a circRNA node in the constructed circRNA-miRNA-mRNA network, but no specific miRNA axis/mechanistic detail is provided for this circRNA in the text.
Confidence score:

0.1768
Other information
Title:

The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer.

Journal: Heliyon
Published: 2024
PubMed ID: 39027611
Study type:

bioinformatics study
Data availability: dbGaP phs000676
Code availability: -