circRNA basic information
circBase ID: hsa_circ_0001550
Name: hsa_circ_RARS
Synonym: Circ_0001550
Host Gene: RARS
Genomic location(hg19): chr5:167915606-167921655:+
Genomic location(hg38): chr5:168488601-168494650:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC specimens; para-cancer specimens; tumor tissues (xenograft)
Cell lines:

SW480; HCT116; SW620; LOVO; NCM460
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NUCKS1
Associated microRNA: miR-4262
Biological function: Facilitates CRC cell proliferation, metastasis (migration/invasion) and stemness, and suppresses apoptosis; promotes xenograft tumor growth.
Molecular mechanism: Acts as a miRNA sponge for miR-4262 to positively regulate NUCKS1 expression (ceRNA-like regulation).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); stemness (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0001550 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It sponges miR-4262 to up-regulate the downstream target NUCKS1, thereby promoting proliferation, migration/invasion, stemness, and in vivo xenograft tumor growth while inhibiting apoptosis.
Confidence score:

0.7792
Other information
Title:

Hsa_circ_0001550 facilitates colorectal cancer progression through mediating microRNA-4262/nuclear casein kinase and cyclin-dependent kinase substrate 1 cascade.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35698305
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -