| Expression pattern: |
DN |
| Associated gene: |
IL-1beta, IL-6, TNF-alpha |
| Associated microRNA: |
miR-148a-3p, miR-148b-3p, miR-199a-5p, miR-199b-5p |
| Biological function: |
inhibits inflammation and proinflammatory cytokine release in acute pancreatitis |
| Molecular mechanism: |
Potential ceRNA (miRNA sponge) mechanism predicted by TargetScan/miRanda; circRNA-miRNA-mRNA interaction network constructed |
| Biological pathway or process: |
inflammation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Bioinformatics Analysis; Transfection; ELISA; Clinical Sample Validation |
| Clinical significance: |
circ_0007798 expression can be used to grade acute pancreatitis severity and increased gradually with disease severity |
| Description: |
circMAP3K5 (circ_0007798) is down-regulated in acute pancreatitis blood samples and in a cerulein-induced acinar cell model. Functional assays indicate circMAP3K5 suppresses inflammatory cytokine release (IL-1beta, IL-6, TNF-alpha), and bioinformatics suggests a potential ceRNA network involving miR-148a-3p/miR-148b-3p/miR-199a-5p/miR-199b-5p and downstream mRNAs. Clinically, its expression level correlates with and may help grade AP severity. |
| Confidence score: |
0.6956 |