| Expression pattern: |
UP |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-646 |
| Biological function: |
Promotes EC cell proliferation, migration, invasion, glycolysis, cell-cycle progression and xenograft tumor growth, and inhibits apoptosis; knockdown suppresses EC progression. |
| Molecular mechanism: |
circ_0001610 acts as a sponge for miR-646 to regulate STAT3 expression, thereby modulating EC progression and glycolysis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); cell cycle (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0001610 is upregulated in EC clinical samples and may provide a potential strategy for EC therapy. |
| Description: |
hsa_circ_0001610/circ_0001610 is upregulated in endometrial carcinoma tissues and cell lines. Its knockdown suppresses EC progression by reducing proliferation, migration, invasion, glycolysis and xenograft tumor growth while increasing apoptosis, at least partly through the miR-646-STAT3 regulatory axis. |
| Confidence score: |
0.7184 |