| Expression pattern: |
UP |
| Associated gene: |
SLC7A11, GPX4, DDX39A |
| Associated microRNA: |
miR-18a-5p |
| Biological function: |
promotes proliferation, migration and invasion; inhibits ferroptosis in prostate cancer cells |
| Molecular mechanism: |
circDUSP22 acts as a ceRNA sponge for miR-18a-5p to upregulate SLC7A11 and GPX4, thereby attenuating ferroptosis |
| Biological pathway or process: |
ferroptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
The elevated expression of circDUSP22 in plasma may serve as a potential biomarker for diagnosing prostate cancer. |
| Description: |
circDUSP22 is up-regulated in prostate cancer plasma and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-18a-5p to increase SLC7A11 (and GPX4), thereby inhibiting ferroptosis. |
| Confidence score: |
0.8537 |