| Expression pattern: |
UP |
| Associated gene: |
MYH9 |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
Enhances proliferation, migration and invasion; promotes CRC progression; increases cell viability; suppresses apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-542-3p, regulating MYH9. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
High hsa_circ_0000520 expression is associated with adverse prognosis and reduced overall survival and DFS, suggesting it as a prognostic biomarker for CRC. |
| Description: |
hsa_circ_0000520 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a miR-542-3p sponge to regulate MYH9, and high expression predicts poorer survival in CRC patients. |
| Confidence score: |
0.7396 |