circRNA basic information
circBase ID: hsa_circ_0000284
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; paired adjacent normal tissues
Cell lines:

SW620; RKO
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000284 was identified among hypoxia-associated circRNAs and was experimentally validated by qRT-PCR as significantly increased in CRC tissues. The article did not further investigate its biological function or mechanism.
Confidence score:

0.4032
Other information
Title:

Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.

Journal: Oncogene
Published: 2023
PubMed ID: 36418471
Study type:

combined biological and clinical study
Data availability: GEO126094; GEO138589
Code availability: -