| Expression pattern: |
UP |
| Associated gene: |
GET4, BAG6 |
| Associated microRNA: |
- |
| Biological function: |
promotes resistance to radiotherapy; enhances DNA damage repair |
| Molecular mechanism: |
circRNA encodes protein (SNX25-215) that binds GET4 and disrupts BAG6-GET4 interaction, promoting BAG6 nuclear translocation and enhancing DNA damage response/repair |
| Biological pathway or process: |
other pathway/process (promotes); apoptosis (other); cell cycle (other) |
| Detected method: |
Q
B
S
|
| Validation methods: |
circRNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Northern Blot; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; Colony Formation Assay; In Vivo Animal Model; Co-IP; Bioinformatics Analysis |
| Clinical significance: |
Higher circSNX25 expression was associated with significantly worse overall survival (OS) and progression-free survival (PFS) in radiotherapy-treated patients; high circSNX25 linked to radioresistance. |
| Description: |
circSNX25 (hsa_circ_0004874) is up-regulated in radioresistant HCC and correlates with poor OS/PFS in radiotherapy-treated patients. It functions mainly by encoding SNX25-215, which binds GET4 and disrupts BAG6-GET4 interaction, promoting BAG6 nuclear translocation and enhancing DNA damage repair to drive radioresistance. |
| Confidence score: |
0.854 |