circRNA basic information
circBase ID: -
Name: hsa_circ_UBE4B
Synonym: circUBE4B
Host Gene: UBE4B
Genomic location(hg19): chr1:10209242-10221344:.
Genomic location(hg38): chr1:10149184-10161286:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

dorsolateral prefrontal cortex
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CD44
Associated microRNA: hsa-miR-4739, hsa-miR-3192-5p, hsa-miR-328-5p, hsa-miR-6778-5p, hsa-miR-6848-5p, hsa-miR-5787, hsa-miR-6771-5p, hsa-miR-1233-5p, hsa-miR-1249-5p, hsa-miR-4695-5p, hsa-miR-4728-5p, hsa-miR-6754-5p, hsa-miR-7851-3p, hsa-miR-325-5p
Biological function: potential miRNA sponge; promotes expression of CD44
Molecular mechanism: predicted ceRNA mechanism via hsa-miR-328-5p to regulate CD44
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

might serve as a potential biomarker for AD diagnosis and treatment
Description:

circUBE4B is upregulated in AD dorsolateral prefrontal cortex. Bioinformatic prediction suggests it may function as a miRNA sponge (not experimentally validated), with a proposed circUBE4B-hsa-miR-328-5p-CD44 ceRNA axis potentially contributing to AD pathology and biomarker potential.
Confidence score:

0.1768
Other information
Title:

Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.

Journal: Journal of molecular neuroscience : MN
Published: 2024
PubMed ID: 38981928
Study type:

bioinformatics study
Data availability: GSE53697; 10.1007/s12031-024-02236-0
Code availability: -