| Expression pattern: |
UP |
| Associated gene: |
IL6ST, STAT1, IGF1R, HBEGF, KPNA1, TLN2 |
| Associated microRNA: |
miR-194-5p, hsa-miR-194, hsa-miR-620, hsa-miR-1270, hsa-miR-383, hsa-miR-579, hsa-miR-548c |
| Biological function: |
Associated with rheumatoid arthritis disease activity; may promote expression of proliferation-related genes in SW982 cells when circ_0005567 is dysregulated. |
| Molecular mechanism: |
Potential miRNA sponge mechanism involving miR-194-5p; circ_0005567 knockdown increases miR-194-5p and is associated with upregulation of multiple mRNAs (no mRNA downregulation observed). |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Western Blot |
| Clinical significance: |
Plasma circ_0005567 concentration is elevated in RA and may serve as a biomarker associated with disease activity; correlated with DAS28-ESR and swollen joint count. |
| Description: |
circ_0005567 is up-regulated in plasma of rheumatoid arthritis patients and is associated with higher disease activity. In SW982 cells, circ_0005567 knockdown increases miR-194-5p, supporting a potential miRNA-sponge relationship, and is accompanied by increased expression of several proliferation-related mRNAs. |
| Confidence score: |
0.6369 |