circRNA basic information
circBase ID: hsa_circ_0005909
Name: hsa_circ_XPR1
Synonym: circ_0005909
Host Gene: XPR1
Genomic location(hg19): chr1:180793888-180794480:+
Genomic location(hg38): chr1:180824752-180825344:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumors tissues; neighboring non-tumor tissues
Cell lines:

hFOB1.19; HOS; U2OS; SAOS-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: miR-936
Biological function: Promotes osteosarcoma cell viability, colony formation, migration, invasion, EMT, and tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA sponge for miR-936 to upregulate HMGB1.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Luciferase Reporter Assay; RNA Pull-Down; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ_0005909 expression was associated with lower overall survival and with clinical staging and distant metastasis.
Description:

hsa_circ_0005909 (circ_0005909) is up-regulated in osteosarcoma tissues/cells and is associated with poorer overall survival. Functionally, circ_0005909 promotes osteosarcoma malignant behaviors and tumor growth by sponging miR-936, thereby relieving miR-936-mediated repression of HMGB1 (circ_0005909/miR-936/HMGB1 axis).
Confidence score:

0.817
Other information
Title:

Circular RNA hsa_circ_0005909 modulates osteosarcoma progression via the miR-936/HMGB1 axis.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32684842
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -