| Expression pattern: |
DN |
| Associated gene: |
CDR1 |
| Associated microRNA: |
miR-671-5p, miR-7 |
| Biological function: |
Associated with increased migration and proliferation/viability of GBM cells via dysregulation of the miR-671-5p axis; loss of CDR1-AS may contribute to loss of neural differentiation and neoplastic transformation. |
| Molecular mechanism: |
miR-671-5p targets and degrades the circRNA CDR1-AS (AGO2-mediated), leading to decreased CDR1-AS and indirectly decreased CDR1 in GBM. |
| Biological pathway or process: |
migration (inhibits); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
- |
| Description: |
CDR1-AS is down-regulated in GBM biopsies and GBM cell lines. The study supports that miR-671-5p targets/degrades CDR1-AS, which is associated with reduced CDR1 and an altered axis contributing to GBM cell migratory/proliferative phenotypes. |
| Confidence score: |
0.4535 |