circRNA basic information
circBase ID: -
Name: hsa_circ_TGFbeta1
Synonym: circRNA-51213
Host Gene: TGFbeta1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

PC3; C4-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AR, TGFbeta1
Associated microRNA: -
Biological function: circRNA-51213 expression is increased by R-2HG in prostate cancer cells and decreased by AR overexpression, but the study did not define a functional role for circRNA-51213.
Molecular mechanism: R-2HG increases circRNA-51213 expression among TGFbeta1-related circRNAs; AR overexpression decreases circRNA-51213 and reverses its R-2HG-induced upregulation. No downstream mechanism specific to circRNA-51213 was reported.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Transfection
Clinical significance:

-
Description:

circRNA-51213 was identified as a TGFbeta1-related circRNA whose expression is significantly induced by R-2HG in PC3 prostate cancer cells. AR overexpression suppresses circRNA-51213 and reverses its R-2HG-induced upregulation, but the article did not pursue circRNA-51213 functional or mechanistic validation beyond expression analysis.
Confidence score:

0.2586
Other information
Title:

Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling.

Journal: Cancer letters
Published: 2020
PubMed ID: 31846689
Study type:

biological research
Data availability: TCGA; cBioPortal
Code availability: -