circRNA basic information
circBase ID: hsa_circ_0046701
Name: hsa_circ_YES1
Synonym: circ-YES1
Host Gene: YES1
Genomic location(hg19): chr18:745707-751804:-
Genomic location(hg38): chr18:745707-751804:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; lung tissues
Cell lines:

BEAS-2B; H1650; A549; PC-9; HEK 239T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: miR-142-3p
Biological function: promotes NSCLC cell proliferation and migration; promotes tumor development and metastasis
Molecular mechanism: acts as a miR-142-3p sponge to regulate HMGB1 (ceRNA axis)
Biological pathway or process:

proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining
Clinical significance:

supports the application of circ-YES1 probability as a new prognostic marker in NSCLC
Description:

circ-YES1 (hsa_circ_0046701), derived from the YES1 gene, is up-regulated in NSCLC cells and promotes proliferation, migration, and in vivo tumor growth/metastasis. Mechanistically, it functions as a ceRNA by sponging miR-142-3p to upregulate HMGB1, forming the circ-YES1/miR-142-3p/HMGB1 axis.
Confidence score:

0.6536
Other information
Title:

Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.

Journal: Respiratory research
Published: 2023
PubMed ID: 37009887
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -