| Expression pattern: |
UP |
| Associated gene: |
LAMC1 / laminin subunit gamma 1, AGO2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes HCC cell proliferation, migration, colony formation and tumor growth, and decreases apoptosis. |
| Molecular mechanism: |
circ_0124208 acts as a ceRNA sponge for miR-338-3p, thereby increasing LAMC1 expression and promoting HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Could be a useful biomarker for HCC diagnosis and a potential therapeutic target for HCC treatment. |
| Description: |
circ_0124208 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. Functionally, circ_0124208 promotes proliferation, migration, colony formation and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-338-3p to upregulate LAMC1, suggesting potential diagnostic biomarker and therapeutic target value in HCC. |
| Confidence score: |
0.7795 |