| Expression pattern: |
UP |
| Associated gene: |
ZNF704, MST2, YAP1, LATS1/2, TAZ |
| Associated microRNA: |
miR-7978 |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth and lung metastasis in vivo |
| Molecular mechanism: |
circHSDL2 acts as a ceRNA/miRNA sponge for miR-7978 to relieve repression of ZNF704 and dysregulate Hippo signaling (including MST2 and downstream components). |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Sanger Sequencing; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Microarray; RNA-seq |
| Clinical significance: |
potential biomarker and treatment target |
| Description: |
circHSDL2 is up-regulated in breast cancer and promotes proliferation, migration, invasion and metastasis. It functions as a ceRNA by sponging miR-7978 to increase ZNF704, leading to dysregulation/activation of Hippo/YAP signaling (including reduced MST2 and increased downstream phosphorylation markers). |
| Confidence score: |
0.7577 |