| Expression pattern: |
DN |
| Associated gene: |
MX2 |
| Associated microRNA: |
miR-570-3p |
| Biological function: |
Suppresses breast cancer cell survival, viability and proliferation; acts as a tumor suppressor and potential diagnostic or therapeutic biomarker. |
| Molecular mechanism: |
circ_ATAD3B functions as a miR-570-3p sponge and increases MX2 mRNA and protein expression, thereby inhibiting breast cancer cell proliferation through the miR-570-3p/MX2 axis. |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circ_ATAD3B showed favorable diagnostic value for differentiating breast cancer from control samples and may serve as a novel biomarker for diagnosis and treatment. |
| Description: |
circ_ATAD3B is down-regulated in breast cancer tissues and cell lines and acts as a tumor suppressor. It sponges miR-570-3p to increase MX2 expression, thereby inhibiting breast cancer cell viability and proliferation, and shows potential diagnostic and therapeutic biomarker value. |
| Confidence score: |
0.7759 |