circRNA basic information
circBase ID: hsa_circ_0001400
Name: hsa_circ_RELL1
Synonym: circRELL1
Host Gene: RELL1
Genomic location(hg19): chr4:37633006-37640126:-
Genomic location(hg38): chr4:37631384-37638504:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004609
MONDO name: herpes simplex infectious disease
Disease details: Herpes simplex virus-1 / HSV-1 lytic infection
Disease DO ID:
 8566
Disease MeSH ID:
 D006561
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

trigeminal ganglia; peripheral blood mononuclear cells (PBMCs)
Cell lines:

MRC-5; LEC; Akata(-); 293T; HEK-293
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: TTI1 mRNA
Associated microRNA: -
Biological function: inhibits lytic HSV-1 infection; suppresses lytic infection
Molecular mechanism: circRELL1 interacts with TTI1 mRNA (component of mTOR complex); mechanism not fully understood
Biological pathway or process:

other pathway/process (other); viral replication (inhibits)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; Clinical Sample Validation; In Vivo Animal Model
Clinical significance:

-
Description:

circRELL1 (hsa_circ_0001400) is induced by herpesvirus infection and interferon stimulation and acts as an antiviral factor by restricting HSV-1 lytic infection. It was reported to interact with TTI1 mRNA (linked to the mTOR complex), suggesting a potential mechanism for suppressing viral replication.
Confidence score:

0.5297
Other information
Title:

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.

Journal: bioRxiv : the preprint server for biology
Published: 2023
PubMed ID: 37886542
Study type:

combined biological and clinical study
Data availability: HSV-1 infection: SRR19779319, SRR19779318, SRR19787559; HSV-1 murine infection: SRR19792335, SRR19792334, SRR25824398, SRR25824397, SRR25824394, SRR25824396; KSHV infection: SRR20020769, SRR20020770, SRR20020761, SRR20020757, SRR20020758, SRR25816558, SRR25816557, SRR25816556; HCMV lytic infection: SRR5629593, SRR5629594, SRR5629591, SRR5629592, SRR5629589, SRR5629590, SRR5629587, SRR5629588, SRR5629577, SRR5629578, SRR5629575, SRR5629576, SRR5629573, SRR5629574, SRR5629571, SRR5629572; Interferon stimulation: SRR25905055, SRR25905049, SRR25905048, SRR25905050, SRR25905054, SRR25905051, SRR25905053, SRR25905052
Code availability: -