circRNA basic information
circBase ID: -
Name: hsa_circ_SEPT9
Synonym: circSEPT9
Host Gene: SEPT9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer / EC
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; paired non-tumor tissues
Cell lines:

KLE; HEC-1-B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: miR-186 gene
Associated microRNA: miR-186
Biological function: circSEPT9 promotes endometrial cancer cell invasion and migration and suppresses the inhibitory effect of miR-186 on these cell behaviors.
Molecular mechanism: circSEPT9 downregulates miR-186 by increasing methylation of the miR-186 gene.
Biological pathway or process:

migration (promotes); invasion (promotes); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

RT-qPCR; Clinical Sample Validation; MSP (Methylation-Specific PCR); Transfection; Transwell Assay
Clinical significance:

-
Description:

circSEPT9 is upregulated in endometrial cancer tissues and functions as a pro-metastatic circRNA in EC cell models. Mechanistically, circSEPT9 acts upstream of miR-186, increasing methylation of the miR-186 gene and reducing miR-186 expression, thereby promoting EC cell invasion and migration.
Confidence score:

0.5812
Other information
Title:

Circular RNA circSEPT9 Is Upregulated in Endometrial Cancer and Promotes Cell Invasion and Migration by Downregulating miR-186 through Methylation.

Journal: Annals of clinical and laboratory science
Published: 2022
PubMed ID: 35777791
Study type:

combined biological and clinical study
Data availability: -
Code availability: -