| Expression pattern: |
DN |
| Associated gene: |
GAB1 |
| Associated microRNA: |
miR-106b-5p |
| Biological function: |
circPRKCI overexpression protected HK-2 cells from LPS-induced damage by inhibiting apoptosis, inflammation and oxidative stress. |
| Molecular mechanism: |
circPRKCI acts as a ceRNA sponge for miR-106b-5p and thereby positively regulates GAB1 expression. |
| Biological pathway or process: |
apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circPRKCI was decreased in sepsis patients' serum and may provide a novel biomarker for sepsis-induced injury. |
| Description: |
circPRKCI is down-regulated in sepsis patient serum and LPS-treated HK-2 cells. Its overexpression alleviates LPS-induced HK-2 cell apoptosis, inflammation and oxidative stress by sponging miR-106b-5p and increasing GAB1 expression, suggesting potential biomarker or therapeutic relevance in sepsis-induced AKI. |
| Confidence score: |
0.7032 |