| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-21 |
| Biological function: |
circC3P1 restrains kidney cancer cell viability, growth, migration, and invasion, and promotes apoptosis. |
| Molecular mechanism: |
circC3P1 negatively regulates miR-21, promotes PTEN expression through the miR-21/PTEN axis, and inactivates PI3K/AKT and NF-kappaB signaling pathways. |
| Biological pathway or process: |
PI3K/AKT (inhibits); NF-kappaB (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
circC3P1 may present a new target for diagnosis or clinical therapy of kidney cancer. |
| Description: |
circC3P1 is downregulated in kidney cancer tissues and functions as a tumor suppressor in KC cells. Its overexpression reduces cell viability, migration, and invasion, induces apoptosis, negatively regulates miR-21, restores PTEN expression, and inhibits PI3K/AKT and NF-kappaB signaling pathways. |
| Confidence score: |
0.6261 |