| Expression pattern: |
UP |
| Associated gene: |
SOX4, SRY-box transcription factor 4, cyclin D1, vimentin, Bax, Ki-67 |
| Associated microRNA: |
miR-423-5p |
| Biological function: |
Circ_0039411 promotes colony formation, migration, invasion, glycolysis, malignant behaviors, and xenograft tumor growth, and inhibits apoptosis in papillary thyroid carcinoma. |
| Molecular mechanism: |
Circ_0039411 functions as a miRNA sponge for miR-423-5p and positively regulates SOX4 expression through the miR-423-5p/SOX4 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ_0039411 is up-regulated in papillary thyroid carcinoma tissues and cell lines. It acts as an oncogenic circRNA that promotes malignant phenotypes and glycolysis while suppressing apoptosis, partly through sponging miR-423-5p to increase SOX4 expression. Knockdown of circ_0039411 also suppresses xenograft tumor growth in vivo. |
| Confidence score: |
0.7548 |