circRNA basic information
circBase ID: hsa_circ_0005741
Name: hsa_circ_FBXW4
Synonym: -
Host Gene: FBXW4
Genomic location(hg19): chr10:103384501-103436193:-
Genomic location(hg38): chr10:101624744-101676436:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000960
MONDO name: diabetic peripheral angiopathy
Disease details: diabetic vascular complications
Disease DO ID:
 11713
Disease MeSH ID:
 D003925
Disease NCIt ID:
 C35610
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HUVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4254, hsa-miR-6837-3p, hsa-miR-6813-3p, hsa-miR-4518, hsa-miR-6768-3p
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0005741 is up-regulated in high glucose-induced HUVECs (validated by RT-qPCR), suggesting it is associated with hyperglycemia-related endothelial dysfunction, but no specific downstream mechanism or functional assays were reported for this circRNA.
Confidence score:

0.1904
Other information
Title:

Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.

Journal: FEBS open bio
Published: 2019
PubMed ID: 31369204
Study type:

biological research
Data availability: available from the corresponding author on reasonable request
Code availability: -