circRNA basic information
circBase ID: hsa_circ_0091581
Name: hsa_circ_GPC3
Synonym: circ_0091581
Host Gene: -
Genomic location(hg19): chrX:132887508-132888203:-
Genomic location(hg38): chrX:133753481-133754176:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent normal tissues
Cell lines:

Huh7; SNU-387; THLE-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FOSL2, Ago2, RISC
Associated microRNA: miR-591
Biological function: Circ_0091581 acts as an oncogene in HCC, promoting cell viability, colony formation, migration, invasion, metastasis, cell cycle progression, and tumor growth, while inhibiting apoptosis.
Molecular mechanism: Circ_0091581 functions as a competing endogenous RNA by sponging and negatively regulating miR-591, thereby increasing FOSL2 expression and promoting HCC progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Circ_0091581 may provide a new potential molecular target for HCC treatment.
Description:

Circ_0091581 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC cell viability, colony formation, migration, invasion, cell-cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0091581 sponges miR-591 to relieve repression of FOSL2, forming a circ_0091581/miR-591/FOSL2 regulatory axis.
Confidence score:

0.7053
Other information
Title:

Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis.

Journal: Digestive diseases and sciences
Published: 2021
PubMed ID: 33040214
Study type:

combined biological and clinical study
Data availability: -
Code availability: -