| Expression pattern: |
UP |
| Associated gene: |
YY1 |
| Associated microRNA: |
miR-186-5p |
| Biological function: |
Promotes lung cancer cell proliferation, migration and invasion; suppresses cell senescence; accelerates tumor growth in vivo. |
| Molecular mechanism: |
Forms a positive feedback loop where circCTNNB1 sponges miR-186-5p to upregulate YY1, and YY1 transcriptionally activates circCTNNB1; circCTNNB1 promotes Wnt pathway activation. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (other); senescence (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circCTNNB1 expression in lung cancer tissues is associated with poor prognosis. |
| Description: |
circCTNNB1 is up-regulated in lung cancer and associated with poor prognosis. It promotes proliferation, migration and invasion while suppressing senescence, and enhances tumor growth in vivo. Mechanistically, circCTNNB1 sponges miR-186-5p to increase YY1, and YY1 transcriptionally activates circCTNNB1, forming a positive feedback loop that activates the Wnt/beta-catenin pathway. |
| Confidence score: |
0.8586 |